Uncle Grandpa (Cartoon Network)
Goodnight grandpa, after five seasons.
Underground (WGN America)
Cancelled after two seasons; with show hoping to continue at a new network
Unusually Thicke (Pop)
Cancelled/ended after two seasons due to the death of star Alan Thicke
Upscale with Prentice Penny (truTV)
Axed after one season
Ultimate Spider-Man (Disney XD)
Cancelled after four seasons and replaced by a new Spider-Man series.